Manchester United visit the Emirates Stadium on New Year's Day to take on an Arsenal side that snatched defeat from the jaws of victory against Chelsea on Sunday.
Premier League leaders Liverpool will be aiming to win an 11th game in a row in the English top flight when they host Sheffield United at Anfield on Thursday.
Jose Mourinho's Tottenham Hotspur, meanwhile, travel to Southampton in Week 21, Manchester City host Everton and Chelsea visit Brighton & Hove Albion.
Week 21 Fixtures and Picks
Wednesday, January 1
12:30 p.