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SANTA CLARA — A four-day break apparently wasn’t enough to totally cure tight end George Kittle of his knee injury from last game.

Kittle, who’s missed only one game in his 2 1/2-year career, sustained what appeared to be a hyperextended left knee when hit there by a helmet on the 49ers’ first snap of Thursday’s 28-25 win at Arizona. Coach Kyle Shanahan said after the game Kittle also battled an ankle injury before sitting out the final minutes.

Tight end George Kittle (85) of the San Francisco 49ers celebrates his touchdown in the first quarter over the Arizona Cardinals at State Farm Stadium on Oct.