The last time Georgetown played Xavier, a little more than two weeks ago, the Hoyas took the Musketeers to the limit before losing 96-91 at the Cintas Center in Cincinnati.
A game-tying four-point play with 24 seconds left in regulation by Xavier's Trevon Bluiett (31 points) forced the overtime. The game had 20 ties and 21 lead changes and neither team led by more than five points.
The teams face each other again Wednesday with Georgetown (15-10, 5-9 Big East) hosting the No. 4 Musketeers (24-4, 12-3) in Washington.
The Hoyas have not played since winning at Butler 87-83 on Feb.