West Ham will assess Kurt Zouma and Lucas Paqueta, who have both been nursing knee injuries.
It's unclear whether Mohammed Kudus, Nayef Aguerd, Maxwel Cornet and Said Benrahma will be cleared to play before heading to the Africa Cup of Nations.
Brighton pair Igor Julio and Facundo Buonanotte are both fitness doubts after suffering injuries against Tottenham last Thursday.
Pervis Estupinan scored in that game on his return from a muscle problem.
MATCH FACTS
Head-to-head
- In this season's reverse fixture in August, West Ham earned their first Premier League victory against Brighton at the 13th attempt (D6, L6).