Southampton midfielder Moussa Djenepo is a doubt after missing training during the week because of illness.
West Ham pair Craig Dawson and Angelo Ogbonna were both injured during Thursday win over Anderlecht and will be assessed.
Michail Antonio, Kurt Zouma and Thilo Kehrer all missed that match but should be fit, while Maxwel Cornet is out.
CHRIS SUTTON'S PREDICTION
It's hard to judge Southampton off the back of their last game, because it was at Etihad Stadium and everyone loses there.
But Saints will need to be much better than they were last last time out at St Mary's, when they were beaten by Everton.