Manchester United manager Erik ten Hag says Lisandro Martinez was taken off against Wolves as a precaution and will be fit.
Sofyan Amrabat is back from the Africa Cup of Nations and Victor Lindelof should be available, but Mason Mount is out and Aaron Wan-Bissaka is a doubt.
West Ham remain without Lucas Paqueta and Michail Antonio due to injury.
Defender Nayef Aguerd could feature following Morocco's exit from the Africa Cup of Nations.
MATCH FACTS
Head-to-head
- Manchester United are unbeaten in their last 15 home league games against West Ham.