Sheffield Wednesday make two changes from their 5-0 win over Cambridge in League One last time out.
Mallik Wilks and Callum Paterson drop out with Dominic Iorfa and former Manchester City youth midfielder Fisayo Dele-Bashiru coming in.
Newcastle make eight changes from their 0-0 draw with Arsenal in the Premier League on Tuesday.
Eddie Howe said he would welcome the fixture congestion that a cup run would bring on Friday.
Only Sven Botman, Sean Longstaff and Joelinton keep their place, while goalkeeper Martin Dubravka is straight back in after being recalled from a loan spell at Manchester United.