Watford's January signing Mauro Zarate is out for the season after suffering a serious knee injury against West Ham.
Full-back Daryl Janmaat is nursing a groin injury and his fitness will be assessed ahead of Saturday's game.
Southampton goalkeeper Fraser Forster is expected to start after overcoming a minor thigh issue picked up in the EFL Cup final last Sunday.
Defender Martin Caceres awaits his Saints debut, while Virgil van Dijk is still sidelined with an ankle injury.
MOTD COMMENTATOR'S NOTES
Steve Wilson: "This is the only Premier League game Southampton will play between 11 February and 19 March, so Claude Puel will be especially keen to see a points return from Vicarage Road.