Watford will begin life back in the Premier League when they host Aston Villa on the opening day.
However, the months of November and December have thrown up a brutal run for the Hornets, where they will face Arsenal, Manchester United, Leicester, Chelsea and Manchester City in a horrid sequence of games for the newly-promoted side.
Xisco's men will then end the season with a tough trip to Stamford Bridge to face Thomas Tuchel's Blues side.
Read the full list below:
14/08/2021 15:00 Aston Villa (h)
21/08/2021 15:00 Brighton (a)
28/08/2021 15:00 Tottenham Hotspur (a)
11/09/2021 15:00 Wolverhampton (h)
18/09/2021 15:00 Norwich City (a)
25/09/2021 15:00 Newcastle United (h)
02/10/2021 15:00 Leeds United (a)
16/10/2021 15:00 Liverpool (h)
23/10/2021 15:00 Everton (a)
30/10/2021 15:00 Southampton (h)
06/11/2021 15:00 Arsenal (a)
20/11/2021 15:00 Manchester United (h)
27/11/2021 15:00 Leicester City (a)
30/11/2021 19:45 Chelsea (h)
04/12/2021 15:00 Manchester City (h)
11/12/2021 15:00 Brentford (a)
14/12/2021 19:45 Burnley (a)
18/12/2021 15:00 Crystal Palace (h)
26/12/2021 15:00 Wolverhampton (a)
28/12/2021 15:00 West Ham United (h)
01/01/2022 15:00 Tottenham Hotspur (h)
15/01/2022 15:00 Newcastle United (a)
22/01/2022 15:00 Norwich City (h)
08/02/2022 19:45 West Ham United (a)
12/02/2022 15:00 Brighton (h)
19/02/2022 15:00 Aston Villa (a)
26/02/2022 15:00 Manchester United (a)
05/03/2022 15:00 Arsenal (h)
12/03/2022 15:00 Southampton (a)
19/03/2022 15:00 Everton (h)
02/04/2022 15:00 Liverpool (a)
09/04/2022 15:00 Leeds United (h)
16/04/2022 15:00 Brentford (h)
23/04/2022 15:00 Manchester City (a)
30/04/2022 15:00 Burnley (h)
07/05/2022 15:00 Crystal Palace (a)
15/05/2022 15:00 Leicester City (h)
22/05/2022 16:00 Chelsea (a)
All fixtures are subject to change once live TV schedule has been finalised.