DeJon Jarreau added 16 points, eight rebounds and six assists, and Justin Gorham and Fabian White Jr. had 10 points apiece for Houston, which won its third straight and reached 20 wins for the sixth consecutive season. The Cougars shot 60% and made 15 of 33 3-pointers.
Houston forced the Bulls (8-10, 4-8) into 15 turnovers and converted those into 22 points.
Xavier Castaneda scored 11 points and Caleb Murphy added 10 for USF, which has lost five of six. The Bulls shot 37%.
The Cougars jumped out to a 54-16 lead with four minutes left in the first half by outscoring USF 47-10, including a 26-0 run.