The Cougars forced Cincinnati into 13 turnovers, which Houston converted into 22 points.
The margin of victory was the largest for either team in the series, besting a 115-78 win by the Bearcats in Dec. 1998. Cincinnati leads the series with Houston 34-6.
Jeremiah Davenport scored 11 points and Tari Eason added 10 points for the Bearcats (7-8, 5-5), who saw their four-game winning streak snapped. Cincinnati shot 30%.
Houston outscored the Bearcats 32-7 over the final 11 minutes of the first half to take a 50-26 lead at the break. Jarreau scored nine points and Mark had eight in the half-ending run.