Collin Holloway led Georgetown (6-10, 0-5) with a career-high 25 points and Dante Harris added 17. Georgetown has lost six straight and now starts Big East play with five straight losses for the first time in program history.
Jermaine Samuels had 18 points for Villanova, which avoided back-to-back losses after dropping a rare home game to Marquette on Wednesday. The Wildcats shot 53.6 % from the field and made all 16 free throws.
Coach Jay Wright's program improved to 23-13 against Georgetown.
Georgetown led 47-39 a few minutes into the second half after a Holloway 3-pointer.