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Fansided · Nov 1, 2025

Virginia Tech vs. Louisville: Final odds and prediction

Vanderbilt v Virginia Tech | Ryan Hunt/GettyImagesComing off a thrilling 42-34 double overtime win over California last Friday night at Lane Stadium, the Virginia Tech football team will look to pull off an upset on Saturday afternoon when Louisville enters Blacksburg as a double-digit favorite.

Virginia Tech will need to establish the run if they are going to hang around with the Cardinals, who are still in the thick of the ACC race for a spot in the ACC Championship Game in December in Charlotte. Let's take a look at the latest odds and give a prediction for the game.

Virginia Tech vs. Louisville: Odds

Moneyline

Louisville -425

Virginia Tech +330

Louisville -10.5 (-110)

Virginia Tech +10.5 (-110)

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