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Iowa State Cyclones vs. Virginia Cavaliers Betting Odds, March Madness Pick

After opening this NCAA tournament with a pair of wins/covers the Virginia Cavaliers are now 7-1 against the spread over their last eight games. They'll try to keep the cash flowing when they meet Iowa State in a Midwest Region semifinal Friday night in Chicago.

Point spread: The Cavaliers opened as 4.5-point favorites; the total was 140.5, according to sportsbooks monitored by Odds Shark. (Line updates and matchup report)

March Madness pick, via Odds Shark computer: 69.8-63.8 Cavaliers

Why pick Iowa State to cover the spread

The fourth-seeded Cyclones also advanced to the Sweet 16 for the second time in the last three seasons by getting past Arkansas-Little Rock on Saturday 78-61.