Top-ranked Villanova has lost starting guard Phil Booth after the junior broke a bone in his right hand during the team's win over Providence on Tuesday night.
Booth, who was limited to three games last season because of a knee injury, is averaging 11.6 points, 3.3 rebounds and 3.2 assists this season for the Wildcats.
Booth scored 21 points in a win over Xavier earlier this month, and had emerged as a key player for coach Jay Wright this season.
"All of us are disappointed for Phil," Wright said in a statement.