Kendall Ellis anchored the Trojans to victory at Hayward Field, rallying to edge Purdue's Jahneya Mitchell at the finish line. USC won in 3 minutes, 27.06 seconds, and Purdue finished in 3:27.13.
That gave the Trojans 53 team points, one more than Georgia and two ahead of Stanford, which didn't have entries in the relay.
Saturday, USC got a win from Anglerne Annelus in the 200 (22.76), seconds from Ellis (400) and Anna Cockrell (400 hurdles) and a third from its 400 relay.
Georgia was denied its second team title of the meet after the Bulldogs claimed the men's Friday.