Miles Reynolds scored a season-high 20 points, Christian James added 16 and Oklahoma maintained its stifling defense in an 81-70 victory over Southern California on Saturday night.
Reynolds, a graduate transfer from Pacific, has scored 14 or more in four of the last five games after not exceeding 12 in the first five.
Nick Rakocevic led the Trojans (5-5) with 17 points and 15 rebounds. USC trailed 40-28 at halftime, but closed to within 51-47 on a rebound basket by Rakocevic with 13:49 to play. The Sooners went on a 12-1 run capped by a 3-pointer by James and were never pressured again.