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USC hands No. 21 Colorado first loss and takes control of the Pac-12 South

The USC defense’s All-America candidate, linebacker Cameron Smith, stood on the sideline wearing his jersey over sweats. The Colorado offense’s All-America candidate, wide receiver Laviska Shenault, looked as unstoppable as advertised in the second quarter when he took a wildcat formation snap and ran untouched for a 49-yard touchdown to help the Buffaloes strike first in Saturday’s Pac-12 South showdown.

If there was ever a scenario that was not going to be favorable for the Trojans, it was this one — USC’s defense, always susceptible to the big play and now without its best player, having to slow a Colorado offense that had racked up 38 points per game en route to a No.