Hakim Ziyech has been dropped from the Ajax team that will face Getafe in the second leg of their Europa League round of 32 fixture.
The 26-year-old is suffering from a calf injury and will miss Thursday's crucial outing at the Johan Cruijff ArenA.
A week ago, Ziyech played for the duration of the match as Ajax bowed to a 2-0 defeat in Getafe, and they now face an uphill task to overturn the result and advance to the next round of the European competition without their star player.
The Moroccan playmaker missed Sunday's league defeat against Heracles as Erik ten Hag's side were dealt a blow in their Eredivisie title race.