The Tottenham Hotspur Stadium hosts a vital game at both ends of the table as Spurs welcome Brighton to the north of the capital.
Mauricio Pochettino's men were beaten at Manchester City on Saturday but remain in the top four thanks to Arsenal's defeat against Crystal Palace.
The battle for the final Champions League places looks like going down to the wire and Tuesday's game is a match where the hosts cannot afford to drop points.
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Brighton, too, will be desperate to get something from the game, as they sit just a place and three points above the relegation zone following a key home loss to 18th-placed Cardiff.