Cristiano Ronaldo has been left out of the Portugal squad for the friendly matches with Saudi Arabia and the United States.
The Real Madrid star, who has scored only one goal in La Liga this season, has been omitted by head coach Fernando Santos along with fellow experienced forwards Ricardo Quaresma and Nani.
Monaco forward Marcos Lopes leads a quartet of uncapped players called up, with Real Sociedad's Kevin Rodriguez, Lille's Edgar Ie and Braga's Ricardo Ferreira in to bolster Santos' defensive options.
Wolves' Ruben Neves, and Euro 2016 hero Eder are also included.
"We have a group of players we've called up to analyse," Santos told a news conference on Friday.