Thembi Kgatlana and Charity Adule enjoyed a winning start, while Dorine Chioguoe endured a losing debut as Eibar defeated Real Betis 1-0 in Sunday's Spanish Primera Iberdrola encounter.
South Africa striker Kgatlana joined Eibar from Portuguese side SL Benfica this summer, while Equatorial Guinea defender Chioguoe teamed up with Betis from Spanish rivals Logrono in July.
Iker Dorronsoro handed Nigeria's Adule a starting place in their first top-flight game since 2009, while offering the Banyana Banyana star her first outing as a substitute for his newly-promoted side.