Jan Siewert's side are back in the second tier after being relegated from the Premier League last term but will be targeting an immediate return to the top flight.
Derby's dreams of a Premier League place were dashed by defeat against Aston Villa in the Championship play-off final in May. Since then, manager Frank Lampard has departed for Chelsea, with Phillip Cocu taking up the reins at Pride Park.
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Huddersfield are chalked up as bet365's 23/20 (2.15) favourites to kick off their Championship challenge with victory at John Smith's Stadium.