Antonio Conte set a club record as he became the first Inter coach to win his first five Serie A games at the helm after overseeing a 1-0 victory against Lazio.
The Nerazzurri extended their perfect start to the top-flight season courtesy of Danilo D'Ambrosio's first-half header at San Siro.
Wednesday's triumph took Inter back above Juventus at the summit, making it a maximum return of 15 points so far in a promising campaign.
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“It was a tough, important victory against a very strong side, who have been working together for four years and have done nothing but strengthen in recent seasons.