Horoya AC are set to lock horns with Bidvest Wits in the Caf Confederation Cup Group C match at Stade du 28 Septembre on Sunday.
The Guinean champions remain undefeated in the group stage having drawn 0-0 with Malian giants AC Djoliba in their previous match.
Lamine N'Diaye's side will advance to the quarter-finals if they avoid a defeat against a struggling Wits outfit.
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The Clever Boys remain winless in their debut appearance in the group stage having lost 2-1 to Libyan outfit Al Nasr in the previous game.
Gavin Hunt will be keen to ensure that Wits' slim hopes of reaching the knockout phase stay alive with a win against the 1978 Caf African Cup Winners' Cup winners.