Bayelsa Queens have been drawn against Rivers Angels, while Confluence Queens will battle Adamawa Queens in the Nigeria Women's Premier League Super Four tournament in Lagos.
The two clashes between the country's women top-flight, who have eight NWPL titles between them, were the standout ties from the Super Four draw held at Agege Stadium on Wednesday.
Bayelsa Queens will be looking to reach their eighth final in the history of the championship, while Rivers Angels are eyeing their ninth appearance in the South-South derby in Lagos.
In August, the league defending champions defeated the 2018 Aiteo Cup winners 2-0 to claim the NWPL Champions Shield in Yenagoa - a feat they will hope to repeat this season.