Manchester City striker Sergio Aguero will not recover from his knee injury in time to face Real Madrid in the Champions League, Pep Guardiola has confirmed.
Aguero sustained meniscus damage during last month's 5-0 Premier League win over Burnley and was operated on by Guardiola's preferred surgeon, Dr Ramon Cugat.
A four-to-six-week recovery period appeared to place Aguero in contention for the August 7 second leg with Madrid, which UEFA this week announced was clear to take place behind closed doors at the Etihad Stadium .
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City hold a 2-1 advantage over the 13-time European champions but, after Friday's draw paired the winner of their last-16 tie against Lyon or Juventus , they will have to try and seal a place at the final stages in Lisbon without their all-time record goalscorer.