A second-half Jordan Ayew penalty was enough to secure Ghana a 1-0 away triumph over Sao Tome and Principe in the 2021 Africa Cup of Nations qualifiers on Monday.
The Crystal Palace striker's effort earned the Black Stars all three points in the Group C matchday two fixture at Stade Nacional 12 Julho.
With two straight wins following Thursday's 2-0 triumph over South Africa, the West Africans have moved to the top of the table.
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Ghana coach James Kwasi Appiah made one change to his starting line-up, replacing Sassuolo midfielder Alfred Duncan with Saudi-based Samuel Owusu.