Ghana are Afcon veterans, having won the tournament on four occasions (1963, 1965, 1978 and 1982), but can they end their long wait for a continental crown in Egypt?
The title has eluded the Black Stars since 37 years, during which time they've recorded five second-place finishes, one third-place and one four fourth-place.
In the 2019 Afcon qualifiers, Ghana played four matches in Group F instead of six, following the disqualification of Sierra Leone, winning three and losing one.
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They finished atop their group with nine points, ahead of second-placed Kenya on seven.