It will be the first top-flight fixture to be played at Bramall Lane in 12 years and the stage, then, is surely set for an electric atmosphere in South Yorkshire.
Latest odds
The Blades bagged a point against AFC Bournemouth at Vitality Stadium last weekend. Chris Wilder's charges are available at 29/20 (2.45) with bet365 to claim their first win of the campaign at the second attempt.
Editors' Picks
Crystal Palace, too, were held in their opening match of the season, playing out a goalless draw with Everton at Selhurst Park.