Real Madrid have confirmed that Isco has sustained a hamstring injury, which makes him a major doubt for Thursday's clash with Valencia.
Isco was an unused substitute during Madrid's 3-1 home win over Eibar on Sunday, which marked their first game back following the three-month coronavirus-enforced break in the season.
The 28-year-old hasn't featured for Zinedine Zidane's side since their 2-0 victory over Barcelona on March 1, and his wait to get back on the pitch now looks likely to be extended for a significant period.
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Madrid have released an official statement confirming Isco has suffered damage to his right thigh ahead of Valencia's arrival at Santiago Bernabeu.