Orlando Pirates and Mamelodi Sundowns will play their respective Nedbank Cup Last 16 matches on February 27, with the Brazilians kicking off the day, before the Soweto giants are in action later on.
All matches of this round will be played on the weekend of February 26 to 28.
Sundowns host GladAfrica Championship side Polokwane City at 15:00, four days after their Caf Champions League Group B fixture away at Algerian side CR Belouizdad.
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Pirates kick off their fixture away at Maritzburg United three hours later and three days after facing SuperSport United in the league, again on the road.