Atletico Mineiro and Palmeiras are already through to the last 16, but who will join them in this penultimate round of fixtures?
The CONMEBOL Copa Libertadores is up and running once more, with the group stage now underway for 2021.
Thirty two teams from across the South American continent have won passage into the first round proper of the competition, either through automatic qualification or by fighting through Libertadores' preliminary rounds.
Both the Argentine and Brazilian clubs have tasted glory in this tournament and will be desperate to make a claim for one of those spots with a strong performance.