According to a statement released by Caf, Mamale lost his life at a local hospital in Kinshasa on Thursday but the cause of his death is still unknown at this stage.
Mamale was a full international with the Democratic Republic of Congo and he represented them in two separate Africa Cup of Nations (Afcon).
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The 1996 edition which was held in South Africa was his first and his second appearances at the games four years later.
"Former DR Congo forward Emeka Essanga passed away on Thursday (25 June 2020) at a local hospital in Kinshasa, his family has announced.