Asante Kotoko have suffered their second consecutive loss in the Ghana Premier League as they fell 1-0 away to Medeama on matchday four on Wednesday.
Prince Opoku Agyemang scored the decisive goal from the penalty spot in just the third minute to claim all three points for the hosts at Akoon Park in Tarkwa.
It is the second straight disappointment for the Porcupine Warriors following a 1-0 home loss to Berekum Chelsea on Sunday.
Elsewhere, Hearts of Oak held their own to settle for a 0-0 draw away with Wafa.