Argentina coach Lionel Scaloni has compared playing football in La Paz to "drowning" as he braces his team for the challenge posed by competing at altitude in Tuesday's clash with Bolivia.
La Albiceleste will be hoping to build on their winning start to World Cup qualification on, having beaten Ecuador 1-0 on Friday.
But up next is one of the trickiest tasks on the South American football calendar; getting a result in La Paz.
Editors' Picks
It is situated roughly 3,650 metres (11,975ft) above sea level, making La Paz the highest capital city on Earth and consequentially causing some visiting athletes to struggle due to the air pressure.