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Super Bowl betting: The unlikely play that can swing millions of dollars

What would become the most lucrative Super Bowl to date for Las Vegas sportsbooks began with a massive loss on the very first play of the game.

In NFL history, only 6.8% of regular-season games -- approximately one in 15 -- have included a safety, according to Elias Sports Bureau. Yet, year after year, the betting public loads up on a safety occurring in the Super Bowl, despite odds nowhere close to 15-1. The going price for a safety in the Super Bowl this year is 7-1.

Meanwhile, savvy pro bettors annually short the Super Bowl safety, sometimes waiting until just before kickoff to risk hundreds of thousands of dollars for a chance at winning a few thousand dollars.