The £30million club-record signing has endured a testing time in north London since completing his move from Newcastle last summer.
Sissoko has been selected by Spurs boss Mauricio Pochettino as he bids to prevent the Hammers from securing a third consecutive home victory over their London rivals.
But it is fair to say the early team news from the London Stadium did not bring joy to all of those supporting the Lilywhites.
Sissoko will line up alongside Eric Dier in central midfield and Spurs fans are worried their side may be lacking the necessary guile to break down their opponents.