Dominic Solanke has undergone surgery on an ankle problem that has been troubling him for two months.
Solanke missed most of preseason after picking up the injury in a friendly at Reading, the first under new boss Thomas Frank.
The £65million England striker returned to make three appearances from the bench but has not started a game this season and not played for more than a month.
Initially, Spurs tried to treat it with rest and injections but this has failed to solve the issue.
'It's time to make a minor surgery,' said Spurs boss Frank ahead of Tuesday's Champions League tie at Bodo/Glimt.