Tottenham's Oliver Skipp is out with a hairline fracture in his heel, while Yves Bissouma has a minor hamstring strain and will be assessed.
New signing Richarlison serves the final match of a two-game ban after throwing a flare into the stand during Everton's win over Chelsea last season.
Southampton wingers Nathan Tella and Theo Walcott are both sidelined with respective knee and fitness issues.
Full-back Tino Livramento is the only long-term absentee.
Manager Ralph Hasenhuttl is expected to hand debuts to a number of players, including goalkeeper Gavin Bazunu and attacking midfielder Joe Aribo.