Harry Kane is expected to face Arsenal despite an unspecified knock keeping him out of Tottenham's Europa League tie on Thursday.
Defender Toby Alderweireld might also feature, having returned to training this week following a groin problem.
Arsenal midfielder Thomas Partey is close to full fitness after a thigh injury and is hoping to be involved.
David Luiz, who suffered a cut to the head in a collision with Wolves striker Raul Jimenez last weekend, could play.
MOTD COMMENTATOR'S NOTES
@SimonBrotherton: Jose Mourinho has never lost a home match to Arsenal in his managerial career and his team are in good form and top of the league after beating Manchester City and drawing at Chelsea in their last two league games.