Tottenham captain Hugo Lloris and defender Toby Alderweireld will both miss Sunday's game at home to Crystal Palace through injury.
Mauricio Pochettino said the pair will undergo scans on Friday, with the club set to learn whether either have a chance of being fit for the north London derby against Arsenal later this month.
Alderweireld suffered a hamstring strain and Lloris a groin injury during Spurs' 3-1 win over Real Madrid on Wednesday and they now face a race against time to line up against the Gunners on November 18.
"They are now going to do a scan this afternoon, tomorrow we'll have a better idea," Pochettino said.