Tottenham's European bid was left in tatters after Brentford mounted a remarkable second-half comeback to leave Harry Kane's early stunner worthless.
Talisman Kane opened the scoring early on on what may prove to be his final home game for the club, having collected a flick from a free-kick and dispatched into David Raya's top corner.
However, the stubborn visitors rallied after the interval and pulled level, Bryan Mbeumo firing low from the edge of the penalty area. Just 12 minutes later, he notched his brace after racing through and slotting home.