Dejan Kulusevski has undergone knee surgery and will not play in the Europa League final.
It is the latest blow to Tottenham who are already without creative midfielders James Maddison and Lucas Bergvall for the showdown with Manchester United in Bilbao on Wednesday.
Maddison and Bergvall will not play again this season and although Spurs have not specified a timeframe for Kulusevski’s absence his season is also most likely to be over.
The 25-year-old Sweden international was Tottenham’s best player by some distance during the first half of the season until February when a foot injury ruled him out for six weeks.