Saturday's Premier League clash at Wembley is followed on Monday by a meeting of the clubs' Under-23 sides in the Premier League 2. The latter represents another chance for Wayne Burnett's charges to climb off the foot of the table, but a top performance will be required against a Toffees outfit that's currently fourth in the standings.
In between those matches, Spurs Ladies travel to face Millwall Lionesses in the Women's Super League 2 on Sunday, before the Under-18s head to AFC Bournemouth for an FA Youth Cup fourth round tie on Tuesday night.
Here's our weekly run-down of the club's fixtures over the next seven days…
Saturday 13 January 2018
First team: Spurs v Everton (Premier League)
Wembley Stadium, connected by EE, 5.