Ange Postecoglou has signalled he will rest key players when Tottenham play Aston Villa on Friday as he "can't afford to lose another" to injury with the Europa League final less than a week away.
Midfielder Dejan Kulusevski has become the latest first-team regular to suffer an injury that will rule him out of Wednesday's final in Bilbao against Manchester United.
Fellow midfielders Lucas Bergvall and James Maddison are both also set to miss the final, while defender Radu Dragusin is a long-term injury absentee after suffering a serious knee injury in February.