Christian Eriksen was a late withdrawal from the trip to Cyprus after feeling ill on Sunday night.
The in-form playmaker joins suspended duo Dele Alli and Jan Vertonghen on the sidelines, alongside Mousa Dembele (ankle), Victor Wanyama (knee) and long-term absentees Danny Rose and Erik Lamela.
Mauricio was asked how the team would deal with the loss of Christian at his pre-match press conference in Nicosia on Monday evening.
"It’s true we’ll miss Christian but we have to move on,” he said. “We have a strong squad and we have to find a way to perform well and try to win the game.