Manchester United are boosted by the return of six players, with Casemiro, Lisandro Martinez and Luke Shaw all back in training.
Antony is also available, while Amad Diallo and Christian Eriksen have both returned after illness.
Tottenham's latest recruits Radu Dragusin and Timo Werner are likely to make their debuts at Old Trafford.
Cristian Romero is in contention after recovering from a hamstring strain ahead of schedule.
Ben Davies is out with his own hamstring injury, while Giovani Lo Celso is sidelined with a muscle issue.
MATCH FACTS
Head-to-head
- Manchester United have won 24 of their 31 Premier League meetings with Spurs at Old Trafford, drawing three and losing four.