Manchester United's Harry Maguire is available despite injuring his ankle in the Premier League win over Brighton last Saturday.
Manager Ole Gunnar Solskjaer has no new fitness concerns in his squad.
Tottenham head coach Jose Mourinho has not completely ruled out Son Heung-min's chances of recovering in time from a hamstring issue.
Giovani Lo Celso is a doubt with an unspecified injury, while Gareth Bale is not yet ready to feature.
LAWRO'S PREDICTION
It's not just United's back four which is a problem - it is the protection, or lack of it, in front of them that really astonished me against Brighton.