Manchester City midfielder Mateo Kovacic has returned to training following injury but Matheus Nunes is likely to remain out.
John Stones will be involved in the matchday squad and could make his first appearance since 7 November.
Rodrigo Bentancur's long-term injury means that Tottenham are missing 10 players for this fixture.
Yves Bissouma is available following a ban but Cristian Romero serves the final game of a three-match suspension.
MATCH FACTS
Head-to-head
- Manchester City have lost just two of their past 13 Premier League home games against Tottenham.
- However, Tottenham have won five of the seven most recent league meetings, having triumphed in just four of the previous 19.